10 Best Computer Use Agents in 2025

What Are the Computer Use Agents

Computer Use Agents are AI-powered assistants that automate desktop tasks, streamline workflows, and integrate with existing software to boost productivity and efficiency. These agents leverage machine learning, natural language understanding, and automation to handle routine computer tasks such as file management, data analysis, and application control, allowing users to focus on higher-value work.

The following list highlights the 10 best Computer Use Agents in 2025. From Appy Pie’s computer use agents with an intuitive, no-code agent builder to Skyvern’s advanced context-aware automation, these platforms cater to a range of business and professional needs by enhancing operational speed, accuracy, and task delegation.

What Are the Best Computer Use Agents in 2025?

The best Computer Use Agents of 2025 combine AI-driven automation, seamless software integration, and user-friendly interfaces to optimize desktop workflows and enhance productivity. Whether you're managing files, running scripts, or generating reports, these agents handle the heavy lifting so you can focus on strategy and creativity. Tools like AI Agents Builder enable professionals to deploy automation efficiently within their existing systems, offering flexibility similar to what is explained in their detailed overview on what are computer use agents.

1. Appy Pie Computer Use Agents
2. Manus AI
3. Claude Computer Use
4. OpenAI Operator
5. Agent S2
6. Genspark Superagent
7. Ace
8. Proxy AI
9. OWL
10. Skyvern

1. Appy Pie Computer Use Agents

Appy Pie’s Computer Use Agents Builder offers a code-free environment to design and deploy desktop assistants. With its intuitive chat based workflow, anyone on your team can automate repetitive tasks like file organization, email sorting, and data entry without needing programming skills.

By integrating with popular applications—such as Microsoft Office, Google Workspace, and Slack—Appy Pie agents ensure seamless operations across your software ecosystem. Advanced scheduling and trigger-based automation keep workflows running 24/7, reducing manual intervention and minimizing errors.

• Chat or Prompt based workflow builder for easy task automation
• Pre-built connectors for major productivity apps
• Trigger-based and scheduled automation options

2. Manus AI

Manus AI excels at streamlining document-heavy workflows. Its natural language interface allows users to draft, edit, and format documents, generate code snippets, and convert between file types using simple text commands.

Built-in integration with version control systems and cloud drives ensures all changes are tracked and synced. Manus AI also supports custom script execution, letting advanced users embed their own automation within the agent’s framework for highly specialized tasks.

• Natural language document and code generation
• Integration with Git, Google Drive, and Dropbox
• Custom script embedding for advanced automation

3. Claude Computer Use

Anthropic’s Claude Computer Use agent is designed for intelligent summarization, content creation, and multi-application orchestration. It can summarize lengthy reports, draft emails, and coordinate tasks across desktop apps based on your prompts.

With an emphasis on safe, explainable AI, Claude is ideal for regulated industries. Real-time analytics and audit trails allow organizations to monitor agent actions and ensure compliance with internal policies.

• AI-driven summarization and content generation
• Multi-application task coordination
• Audit trails and compliance monitoring

4. OpenAI Operator

OpenAI Operator brings the power of GPT-5 directly to your desktop, enabling natural language command execution, code snippet insertion, and seamless API orchestration. Developers can ask it to run terminal commands, modify configuration files, and integrate with CI/CD pipelines without leaving their workflow.

Its extensible plugin architecture supports custom capabilities—like database queries, monitoring alerts, and cloud service management—making it an indispensable tool for both developers and IT operations teams. The secure execution sandbox ensures commands run safely, with full audit logging for compliance.

• Natural language to terminal command translation
• Plugin system for custom integrations
• Secure execution sandbox with detailed audit logs

5. Agent S2

Agent S2 specializes in scheduling and event-driven automation. By leveraging intelligent triggers—such as calendar events, incoming emails, or file changes—it launches complex workflows that process data, send notifications, or update systems automatically.

With built-in SLA monitoring, retry mechanisms, and detailed execution logs, Agent S2 guarantees reliable task completion, making it ideal for service desks, HR operations, and supply chain management teams that require robust automation with accountability.

• Calendar and email-based triggers for automated workflows
• SLA tracking with automatic retries on failure
• Comprehensive notification system with execution logs

6. Genspark Superagent

Genspark Superagent is designed for data-driven professionals who need to automate spreadsheet and analytics tasks. It can ingest data from Excel and Google Sheets, perform transformations, generate pivot tables, and create visualizations—all through intuitive natural language prompts.

Integrated with BI platforms like Power BI and Tableau, Superagent can push processed datasets and dashboards directly into your reporting tools, streamlining the end-to-end data analysis workflow for marketing, finance, and operations teams.

• Spreadsheet automation and dynamic pivot table creation
• Integration with Power BI, Tableau, and other BI platforms
• Export results to CSV, PDF, and image formats

7. Ace

Ace acts as your personal AI productivity partner, learning your routines and preferences to automate daily desktop tasks. From drafting emails and scheduling meetings to organizing files and setting reminders, Ace adapts to your work style over time.

With a multi-modal interface—including chat, voice commands, and desktop notifications—Ace ensures you can interact in the way that feels most natural. Its machine learning personalization continuously improves task suggestions and execution accuracy.

• Personalized routine automation based on user behavior
• Multi-modal interaction via chat, voice, and system notifications
• Adaptive learning to refine suggestions and workflows

8. Proxy AI

Proxy AI specializes in API-based desktop automation, enabling users to connect local applications with web services through a low-code interface. Drag-and-drop HTTP connectors let you fetch, transform, and visualize data without writing boilerplate code.

With built-in error handling, retry logic, and live dashboards, Proxy AI ensures your critical workflows run reliably. Its secure credential vault and role-based access controls make it a dependable choice for enterprise environments.

• Low-code HTTP connector builder for API integrations
• Error handling and retry policies for robust execution
• Real-time dashboards for monitoring workflow status

9. OWL

OWL provides context-aware desktop assistants that learn your application usage patterns and proactively suggest automations—such as auto-filling forms, opening relevant files, or running routine scripts when needed.

Its machine learning models continuously adapt based on feedback, improving suggestion accuracy over time. OWL integrates seamlessly with Windows and macOS, offering a native experience on both platforms.

• Contextual suggestions based on usage patterns
• Adaptive learning from user feedback
• Native integration with Windows and macOS

10. Skyvern

Skyvern is an enterprise-grade automation platform with a visual editor for multi-step workflows. Create complex scripts that include conditional branches, loops, and API calls—all within a single canvas.

Featuring enterprise security, role-based access, and audit logging, Skyvern ensures strict governance over agent capabilities. It’s ideal for large organizations that require both power and compliance.

• Visual workflow editor with conditional logic and loops
• Role-based access controls and audit logs
• Cross-platform scripting support

How Do Top Computer Use Agents Compare?

Below is a side-by-side comparison of the leading Computer Use Agents, highlighting each one’s main focus, supported operating systems, and pricing model to help you decide which fits your workflow best.

What Key Features Do These Computer Use Agents Offer?

This feature matrix provides an at-a-glance view of which agents include no-code builders, API integrations, context-aware suggestions, scheduling and triggers, and BI/data analysis capabilities.

Why Choose Appy Pie Computer Use Agents for Your Workflow?

Appy Pie Computer Use Agents deliver an accessible, cost-effective way to automate desktop tasks without a single line of code. Their intuitive drag-and-drop interface, extensive app integrations, and scalable architecture make them a perfect fit for businesses of any size. Appy Pie’s approach to workflow automation aligns with modern enterprise needs, as seen in their insights on chatbot software for enterprises, reinforcing the platform’s enterprise-grade capabilities.

• Ease of Use: Appy Pie Agents lowers the barrier for non-technical teams.
• Rich Integrations: Connect with over 100 popular productivity and collaboration apps out of the box.
• Scalable Architecture: From solo users to global enterprises, the platform grows with you.
• Cost-Effective Plans: Pay only for what you use, with flexible pricing tiers.
• Dedicated Support: Onboarding, tutorials, and a vibrant community help you get the most out of your agents.

Conclusion: The Final Take on Computer Use Agents

Computer Use Agents of 2025 empower professionals and organizations to automate repetitive desktop tasks, improve efficiency, and focus on strategic work. By leveraging AI-driven workflows, these agents handle everything from file management and email processing to complex API orchestration.

While Appy Pie stands out for its no-code ease-of-use and broad integrations, specialized platforms like Proxy AI and Skyvern offer advanced capabilities for API-driven and enterprise-grade workflows. Evaluate your needs—whether you require simple triggers or complex visual workflows—to choose the agent that best accelerates your productivity.

Frequently Asked Questions (FAQs)

Which computer use agent is best for API-based automation?

Proxy AI is widely regarded as one of the best options for API-based automation due to its user-friendly, low-code HTTP connector builder that simplifies the process of integrating with external APIs. It also includes robust error-handling capabilities and real-time monitoring dashboards that allow users to identify and resolve issues efficiently. These features make Proxy AI particularly well-suited for developers and IT teams who require dependable, scalable automation across multiple systems and services, much like the techniques outlined in this guide on how to use computer use agents.

How does OWL differ from other context-aware assistants?

OWL sets itself apart from other context-aware assistants by using intelligent analysis of real-time desktop activity to offer proactive automation suggestions. While traditional assistants typically require user commands or manual input to trigger workflows, OWL continuously learns from your behavior—such as application usage, routine actions, and timing patterns—to anticipate your needs. This results in a more seamless and intuitive automation experience that evolves as you work.

What makes Skyvern suitable for large enterprises?

Skyvern is designed specifically for the needs of large-scale enterprises. It provides a powerful visual workflow editor with support for advanced conditional logic, making it easier to build complex automations without requiring deep programming knowledge. Additionally, it features enterprise-grade security measures, including end-to-end encryption, role-based access controls, and comprehensive audit logging. These capabilities help organizations maintain data security, ensure regulatory compliance, and manage workflows at scale with full transparency and control, echoing the priorities explored in this article on best generative AI agents.

Why choose Appy Pie Computer Use Agents for small teams?

Appy Pie is an ideal solution for small teams and startups seeking to automate daily desktop tasks without technical expertise. Its no-code interface allows users to create and deploy automations quickly, while the platform’s flexible pricing—including a free tier—makes it budget-friendly. Whether your team needs to automate tasks like file transfers, application launching, or repetitive data entry, Appy Pie provides a straightforward and cost-effective way to increase productivity without additional infrastructure or staffing costs.

Can these agents run on both Windows and macOS?

Yes, most of the top-rated computer use agents—including OWL, Skyvern, and Appy Pie—offer native support for both Windows and macOS. This ensures maximum flexibility and cross-platform compatibility, enabling teams to build and manage automations regardless of the operating system in use. Such support is particularly beneficial for organizations with hybrid device environments or remote teams using varied hardware setups, as demonstrated by various AI agents examples that operate seamlessly across platforms.